Figure 4

E ₂ increased ERα mRNA expression (A) and protein expression (B) of primary-cultured FIGO stages I endometrial adenocarcinoma cells in a dose-dependent manner. This tendency was similar to that of NPM1 (Figure 3). E₂, 17β-estradiol. *P < 0.05, **P < 0.01, *** P < 0.001 indicate significant differences from those treated with 0 μm/ml E₂.