Figure 1From: The multifaceted role of CD146/MCAM in the promotion of melanoma progression The putative structure of huCD146 protein and mechanisms that CD146 regulates the survival of melanoma. A. The putative structure of huCD146 protein. The CD146 sequence has three conserved motifs: a KKGK motif, a PKC site and a C terminus. The anti-CD146 mAbs that recognise the cognate epitopes in the extracellular domain are shown in the schematic diagram. B. CD146 is involved in both inside-out and outside-in signalling. Activation of the PI3K–AKT pathway can up-regulate the cell surface expression of CD146 (inside-out), and the cell surface expression of CD146 can in turn activate the PI3K–AKT pathway (outside-in).Back to article page