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Figure 4 | Cancer Cell International

Figure 4

From: The multifaceted role of CD146/MCAM in the promotion of melanoma progression

Figure 4

A proposed model is that CD146 promotes angiogenesis and mesenchymal cell migration in melanoma. CD146 possibly induces angiogenesis through the NF-κB p50-IL-6-VEGF signalling pathway. In addition, CD-146 induced IL-6 positively regulates the expression of Wnt5a. In response to the Wnt5a signal, the CD146/Fz3/DVL2 complex is recruited to the tail end of the cell by means of MVB or ER where it assembles actin and myosinII filaments to form the WRAMP structure, which directs tail-end membrane retraction.

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