Natural and synthetic agents mediated targeting of AR. a) SUMOylated AR mediated transcriptional activity activity is reduced. b-c) SENP-1 is a target of AR that deconjugated SUMO from AR thus enhancing AR mediated transcriptional activity. d) Natural and synthetic agents have shown potent inhibitory effects on SENP-1. e) AZD3514 inhibited nuclear accumulation of AR. f) Mahanine promoted nuclear export of AR. g) Urolithins and Curcumin have shown to reduce AR induced transcriptional activity. h) Natural agents also decrease mRNA and protein levels of AR.