Table 1 List of natural agents with notable activity against AR in prostate cancer

Urolithins (Walnut polyphenol metabolites)

PSA ↓

Sánchez-González et al. [24]

Bcl-2 ↓

AR inhibition

Curcumin

AR inhibition

Zhou et al. [25]

Imidazopyridine

PI3K/Akt ↓

Muniyan et al. [26]

AR induced signaling ↓

Atraric acid

Inhibition of intramolecular amino/carboxy (N/C)-terminal interaction of the AR

Hessenkemper et al. [27]

Furanoditerpenoid spongia-13(16),-14-dien-19- oic acid

Yang et al. [28]

AZD3514

AR ↓

Loddick et al. [31]

Rosmarinus officinalis extract

AR ↓

Petiwala et al. [29]

Betulinic acid

AR ↓

Reiner et al. [30]

Isochaihulactone

AR mRNA ↓

Liu et al. [33,34]

Shikonin

AR protein ↓

Jang et al. [32]