S100A7 knockdown decreases NF-κB activity. S100A7 knockdown decreases nuclear factor-κB (NF-κB) activity. Tumor necrosis factor-α (TNF-α) induces NF-κB phosphorylation in NCI-H520 cells, vector control cells (NT) and knockdown cells (S4), though significantly less in the knockdown cells. Representative Western blot of a single experiment is shown with a graph of densitometric analysis of cumulative experiments below (mean ± standard error of the mean; n = 5 per group). *P < 0.05.