Table 2 Clinical characteristics of patients, S100A7 expression and the survival analysis
S100A7 experssion | Log rank | Median | Log rank | Cox regression | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Factors | +(n) | -(n) | P | Total | Survival | Subgroup | Univariate | Multivariate | ||||
P | (Months) | P | HR | 95 % CI | P | HR | 95% CI | P | ||||
Gender | 0.304 | 0.274 | ||||||||||
Female (n = 38) | 14 | 24 | 57.12 | 0.075 | ||||||||
Male (n = 105) | 63 | 42 | 59.20 | 0.024 | ||||||||
Age | 0.29 | 0.451 | ||||||||||
<60y (n = 49) | 30 | 19 | 59.13 | 0.146 | ||||||||
≧60y (n = 94) | 57 | 37 | 52.24 | 0.018 | ||||||||
Tumor size | 0.014 | 0.000 | ||||||||||
T1+T2 (n = 92) | 71 | 21 | 62.3 | 0.0026 | 2.128 | 1.38-3.472 | 0.002 | 1.563 | 1.028-2.859 | 0.047 | ||
T3+T4 (n = 51) | 16 | 35 | 36.2 | 0.437 | ||||||||
Differentiation | 0.473 | 0.269 | ||||||||||
Low (n = 94) | 62 | 32 | 52.8 | 0.016 | ||||||||
Moderate/high (n = 49) | 25 | 24 | 60.5 | 0.162 | ||||||||
Lymph node | 0.063 | 0.000 | 2.846 | 1.93-5.053 | 0.001 | 2.73 | 1.40-3.180 | 0.02 | ||||
N0+N1 (n = 106) | 69 | 37 | 61.5 | 0.012 | ||||||||
N2+N3 (n = 37) | 18 | 19 | 30.8 | 0.165 | ||||||||
Distant M | 0.258 | 0.684 | 1.235 | 0.63-2.158 | 0.392 | |||||||
M0 (n = 131) | 79 | 52 | 59.6 | 0.006 | ||||||||
M1(n = 12) | 8 | 4 | 44.8 | 0.538 | ||||||||
Clinical stage | 0.082 | 0.0013 | 2.35 | 1.364-3.86 | 0.001 | 0.93 | 0.435-1.132 | 0.876 | ||||
I+II(n = 89) | 49 | 40 | 615 | 0.038 | ||||||||
III+IV(n = 54) | 38 | 16 | 37.9 | 0.026 | ||||||||
S100A7 (n = 143) | 87 | 56 | 0.001 | 0.007 | 58.2/43.8 | 1.926 | 1.23-3.28 | 0004. | 2.01 | 1.35-4.157 | 0.002 | |