Effect of paclitaxel and SB
1216 on the mitochondrial membrane potential
) in SK
-3 and MCF-
7 cells. Control cells were incubated without taxane. After 36 h (SK-BR-3) or 60 h (MCF-7) of incubation with tested taxane (100 nM for SK-BR-3 and 300 nM for MCF-7) the mitochondrial membrane potential was assessed using flow cytometry analysis of cells after staining with [DiOC6(3)] (see “Materials and methods”). The collapse of Δψm caused by the application of CCCP is shown (blank areas). The data shown were obtained in one representative experiment of three independent experiments.