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Table 2 PI3k inhibition causes FOXO3a activation in breast cancer cells

From: Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review

First author (Year) Treatment Effect on FOXO3a (Activates/Inactivates) Cellular effects
Espinoza (2011) [25] Zoledronic acid (ZOL) Activates in MDA-MB-231 and MCF-7 measured by nuclear translocation of FOXO3a. Inhibited proangiogenic factor, CCN1 in TNBC
Guo (2004) [34] Wortmannin, EGCG Activates in MCF-7 and ZR-75 cells; and Hs578T and MDA-MB-231 cells, measured as FOXO3a expression and nuclear translocation. Increased ER expression