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Table 4 FOXO3a activation in breast cancer cells increases apoptosis

From: Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review

First author (Year)

Treatment

Effect on FOXO3a (Activates/Inactivates)

Cellular effects

Kong (2010) [35]

miR-155

Inhibits in BT-474 measured by protein expression.

Decreased Bim and p27 expression decreased apoptosis.

Kong (2012) [36]

AZD6244, indirectly as an ATP-uncompetitive inhibitor of MEK ½

Activates FOXO3a in MTDH knock-down, AZD6244 resistant lines.

Increased apoptosis.

Lam (2012) [37]

Aqueous extract of Fagonia

Activates FOXO3a measured by Western blot in MCF7 and MDA231.

Cell cycle arrest and apoptosis.

Lin (2010) [38]

miR-96

Inhibits in BT549, ZR-75-30, Bcap37, MDA-MB231, MDA-MB435, MCF-7, SKBR3 measured as FOXO3a expression and by reporter assay.

Down-regulation of p21 cip1, p27 kip1, CDK and cyclin 1.

Liu (2012) [39]

Arsenic trioxide

Activates in MCF7 measured as nuclear translocation and expression.

Decreased IKKB.

Increased apoptosis.

Stan (2008) [40]

Withaferin.

Activates in MCF-7 (estrogen-responsive) and MDA-MB-231.

Increased Bim expression.

Increased apoptosis.