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Figure 2 | Cancer Cell International

Figure 2

From: Inhibition of the AKT pathway in cholangiocarcinoma by MK2206 reduces cellular viability via induction of apoptosis

Figure 2

MK2206 specifically inhibits phosphorylation at Serine 473 in CCA cells, leading to induction of apoptosis. After 96 hours of MK2206 treatment at the indicated doses, CCLP-1 and SG231 cells were lysed and Western blot analysis was used to determine expression levels of phosphorylated AKT and total AKT in addition to apoptotic markers (Pro-Caspase 3, Pro-Caspase 9, and Survivin).

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