Table 1 Niraparib potentiates the effects of SN-38 in MSI and MSS cell lines
7 day EC50 (nM) | Combination EC50 (shift of SN-38 EC50 in presence of Niraparib) | |||||
|---|---|---|---|---|---|---|
Niraparib | ||||||
Cell line | Niraparib | SN-38 | 125 nM | 250 nM | 1000 nM | |
MSI | DLD1 | 3560 | 3.63 | 0.992 | 1.67 | 1.68 |
HCT8 | 2130 | 3.60 | 2.07 | 1.54 | 1.35 | |
HCT15 | 1685 | 3.77 | 3.47 | 3.44 | 1.73 | |
HCT116 | 6915 | 0.180 | 0.125 | 0.155 | 0.0991 | |
LOVO | 2010 | 3.43 | 2.3 | 3.53 | 2.4 | |
LS174T | 1310 | 0.331 | 0.257 | 0.208 | 0.231 | |
LS180 | 3730 | 0.474 | 0.399 | 0.395 | 0.389 | |
LS411N | 1875 | 3.57 | 1.21 | 1.11 | 0.729 | |
RKO | 1870 | 0.958 | 0.593 | 0.778 | 0.184 | |
RKOE6 | 1270 | 0.730 | 0.426 | 0.422 | 0.464 | |
SNUC2A | >10000 | 3.23 | 3.04 | 2.72 | 2.52 | |
SW48 | >10000 | 1.79 | 0.886 | 0.762 | 0.598 | |
MSS | COLO205 | 1990 | 1.57 | 0.572 | 0.475 | 0.531 |
HT29 | 6880 | 4.29 | 3.07 | 3.64 | 1.75 | |
NCI-H-508 | >10000 | 3.63 | 1.70 | 3.31 | 1.41 | |
SK-CO-1 | 1090 | 0.416 | 0.178 | 0.334 | 0.143 | |
SW403 | >10000 | 3.39 | 1.14 | 1.87 | 0.387 | |
SW480 | >10000 | 29.0 | 11.9 | 11.6 | 8.7 | |
SW620 | 552 | 5.91 | 3.62 | UR | UR | |
SW837 | >10000 | UR | UR | UR | UR | |
SW948 | 7195 | 6.67 | 3.85 | 4.47 | 2.80 | |
SW1116 | >10000 | UR | UR | UR | UR | |
SW1417 | >10000 | 27.7 | 29.2 | 28.3 | 31.0 | |
SW1463 | >10000 | 26.4 | 22.2 | UR | UR | |
T84 | 1460 | 1.01 | 0.491 | 0.352 | 0.210 | |