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Figure 2 | Cancer Cell International

Figure 2

From: The association between Salt-inducible kinase 2 (SIK2) and gamma isoform of the regulatory subunit B55 of PP2A (B55gamma) contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K

Figure 2

Glioma cells with overexpression of B55gamma are insensitive to glucose starvation. A. Overexpression of B55gamma in U87, U135 and U118 glioma cells. Glucose withdrawal induced cell death in U251V cells but U251B55gamma cells were insensitive to glucose withdrawal. Cells were starved of glucose for 12 h, 24 h, 36 h and 48 h and cell viability assay were performed by direct counting of Trypan blue negative cells. B. Cell death and morphological changes in U251V and U251B55gamma cells in response to glucose starvation for 12 hrs and 48 hrs. Columns, mean of three independent experiments; bars, SE. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

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