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Figure 5 | Cancer Cell International

Figure 5

From: Inhibition of miR-191 contributes to radiation-resistance of two lung cancer cell lines by altering autophagy activity

Figure 5

miR-191 modulated Beclin-1 expression in radiation resistant A549 and H1299 cells. (A) Expression status of certain autophagic marker proteins Beclin-1, LC3-II, p62 and GAPDH (loading control) in miR-191-overexpressed A549 cells. (B) Expression status of certain autophagic marker proteins Beclin-1, LC3-II, p62 and GAPDH (loading control) in miR-191-overexpressed H1299 cells. (C) Relative Beclin-1, LC3-II and p62 mRNA expression levels in miR-191 mutant A549 cells. bars represent mean ± S.E. (*p <0.05 vs control, n = 3). (D) Relative Beclin-1, LC3-II and p62 mRNA expression levels in miR-191 mutant H1299 cells. bars represent mean ± S.E. (*p <0.05 vs control, n = 3). (E) Relative Beclin-1, LC3-II and p62 mRNA expression levels in miR-191 overexpressed A549 cells, bars represent mean ± S.E. (*p <0.05 vs control, n = 3). (F) Relative Beclin-1, LC3-II and p62 mRNA expression levels were quantified by qRT-PCR analysis in miR-191 overexpressed H1299 cells, bars represent mean ± S.E. (*p <0.05 vs control, n = 3).

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