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Figure 6 | Cancer Cell International

Figure 6

From: Granulocyte colony-stimulating factor potentiates all-trans retinoic acid-induced granulocytic differentiation in acute promyelocytic leukemia cell line HT93A

Figure 6

Abrogation of G-CSF-induced differentiation with ruxolitinib. HT93A cells were treated with 100 nM ATRA, with or without 50 ng/mL G-CSF, in the presence or absence of ruxolitinib for 7 days. CD11b (A) and CD34 (B) expression are shown. Ruxolitinib had little or no effect on ATRA-induced alterations of CD11b and CD34, but abrogated the enhancing effect of G-CSF. Experiments were independently repeated three times and results are shown as mean ± SD. *p < 0.05 vs. control; #p < 0.05 vs. ATRA.

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