Figure 4
From: PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation
Nuclear localization of YAP is inhibited by inhibition of Geranylgeranylation. MDA-MB-231 cells were treated with atorvastatin (panels d-f) or the geranylgeranyltransferase I inhibitor GGTI-298 (panels g-i) for 48 hrs. The cells were stained with anti-YAP (red) (panels a, d, and g) or DAPI (blue) (panels b, e, and h).
