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Figure 3 | Cancer Cell International

Figure 3

From: RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric cancer cells

Figure 3

RhoGDI2 up-regulates P-gp expression via Rac1. (a) Rac1 activity in MKN-45/RhoGDI2 and MKN-45/GFP was measured as described in materials and methods. Data are expressed as mean ± SD from three independent experiments; *p < 0.001 vs MKN-45/GFP. (b) Western blot analysis of P-gp and Rac1 expression in MKN-45/RhoGDI2, MKN-45/GFP transfected with Rac-1 or Mock siRNA (pictures are representative of three independent experiments). The immunoblot image was quantitated by densitometric analysis (c) (n = 3 independent experiments). Data was shown in folds relative to MKN-45/GFP + NC siRNA. *p < 0.05 vs MKN-45/GFP + NC siRNA, #p < 0.05 vs MKN-45/RhoGDI2 + NC siRNA.

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