Figure 7
Nar enhances the chemosensitivity of human colorectal cancer cells to DNA-acting drugs. Human colorectal cancer cells SW1116 were plated (27 × 103 cells/well) into a 96-well plate at 37°C in a non-CO2 incubator. At 18 h after starting the culture, the cells were treated for 24 h with Nar (1 mM) and various concentrations of camptothecin, CPT doxorubicin, DOX, 5-fluorouracil, 5FU cisplatin, CIP, etoposide, ETP ellipticine, ELP (1 × 10−10– 1 × 10−3 M), carboplatin, CAP (1 × 10−10 – 3.5 × 10−4 M) and cyclophosphamide, CPA (1 × 10−11 – 1 × 10−5 M). Cell proliferation was monitored using an MTT assay.