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Figure 2 | Cancer Cell International

Figure 2

From: Suramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression

Figure 2

Suramin decreases the proliferation of HO-8910 PM and Hela cells. MTT assay showed that HO-8910 PM and Hela proliferation was inhibited in a dose-dependent and time-dependent manner after suramin treatment (a). IC50 value of HO-8910 PM was 319 μg/mL, IC50 value of Hela was 319.1 μg/mL (b). Flow cytometry was used to detect apoptosis rate in HeLa cells (Figure 2c).The level in cells given 300 μg/ml suramin for 48 h was significantly lower than in untreated cells (300 μg/ml group12.91 ± 1.17%vs UCG 5.01 ± 1.07%,p =0.001) (c).

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Cancer Cell International

ISSN: 1475-2867

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