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Table 1 IC 50 mean values for different drugs tested in monolayer and MTS of lung cancer cell lines

From: Multidrug resistance characterization in multicellular tumour spheroids from two human lung cancer cell lines

Drug INER-37 2D (μM). INER-37 MTS (μM). t- student INER-51 2D (μM). INER-51 MTS (μM). t -student
Etoposide 17.9 >500 0.0001 9.9 >500 <0.0001
Teniposide 9.5 >500 0.0003 3.9 >500 <0.0001
Doxorubicin 3.9 >100 <0.0001 7.9 87.3 0.014
Camptothecin 9.1 >100 0.004 0.01 >100 <0.0001
5-Fluorouracil 300 >500 NS 5.0 >500 <0.0001
Methotrexate 300 >500 NS 2.6 >500 <0.0001
Cytosine-Arabinoside 300 >500 NS 0.95 >500 <0.0001
Cisplatin 29.0 74.8 0,033 74.8 25.5 0,003
  1. Five thousand cells per well were plated in 96 well plate previously precoated with or without agarose and the drug cytotoxicity was determinate by MTT assay. Each IC50 value is the average of six independent experiments. The symbol (>) indicates that the IC50 was not reached at the highest concentration tested. NS: Not significant.