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Table 1 Cell viability in human cancer cells treated with various doses of the 4-aryl-4H-chromene derivatives for 72 h

From: Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells

    

R

  
 

 

Cell lines

Concentration (nM)

3-BC

3-NCa

3-TFC

Concentration (nM)

4, 5 MC

HepG2

0

100

100

100

0

100

50

61 ± 2.5

57 ± 3.1

91 ± 3.1

100

67 ± 2.1

55

53 ± 2.4

50 ± 4.2

89 ± 3.6

110

65 ± 1.6

60

50 ± 3.2

33 ± 2.1

87 ± 2.5

120

46 ± 2.5

65

43 ± 2.1

30 ± 3.6

82 ± 2.3

130

45 ± 2.7

70

42 ± 3.1

28 ± 3.3

76 ± 3.2

140

42 ± 3.6

75

40 ± 3.3

22 ± 1.2

65 ± 2.1

150

40 ± 2.5

80

37 ± 1.8

20 ± 2.1

53 ± 3.7

160

28 ± 3.3

T47D

0

100

100

100

0

100

50

80 ± 3.3

74 ± 1.5

86 ± 2.4

100

79 ± 3.5

55

60 ± 2.5

64 ± 2.3

75 ± 5.3

110

68 ± 4.1

60

53 ± 2.3

52 ± 3.5

72 ± 4.2

120

66 ± 4.2

65

51 ± 3.1

48 ± 4.6

64 ± 4.4

130

58 ± 2.4

70

48 ± 4.2

41 ± 2.6

61 ± 2.2

140

51 ± 3.2

75

45 ± 2.1

36 ± 2.5

50 ± 4.2

150

46 ± 4.5

80

42 ± 3.3

35 ± 1.3

44 ± 2.1

160

35 ± 3.2

HCT116

0

100

100

100

0

100

50

50 ± 3.5

50 ± 3.1

85 ± 2.5

100

70 ± 3.5

55

43 ± 2.4

42 ± 3.2

80 ± 3.6

110

67 ± 3.6

60

35 ± 3.2

37 ± 2.5

73 ± 4.5

120

65 ± 2.5

65

28 ± 2.1

30 ± 4.6

70 ± 3.3

130

62 ± 2.3

70

22 ± 4.1

22 ± 3.3

70 ± 1.2

140

60 ± 3.2

75

17 ± 3.1

15 ± 1.7

67 ± 3.4

150

54 ± 2.1

80

12 ± 3.3

12 ± 2.8

65 ± 3.0

160

50 ± 3.7

  1. Cell viability was evaluated by MTT assay. Data were expressed as a percentage of control measured in the absence of the compounds. Each point represents the mean ± SD of three independent experiments. (P < 0.05)
  2. aData from Ref. [21]