From: AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis
Group N | G vs. A | GA vs.AA | GG vs.AA | GG + GA vs.AA | GG vs.GA + AA | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR(95 % CI) | I 2â–˛ | P Q â–˛ | OR(95 % CI) | I 2 | P Q | OR(95 % CI) | I 2 | P Q | OR(9 % CI) | I 2 | P Q | OR(95 % CI) | I 2 | P Q | ||
Overall | 10 | 1.21(1.05–1.40) | 39.5 | 0.094 | 1.00(0.81–1.14) | 12.1 | 0.332 | 1.30(1.04–1.63) | 35.9 | 0.121 | 1.10(0.91–1.42) | 27.6 | 0.362 | 1.36(1.17–1.58) | 19.5 | 0.263 |
Ethnicity | ||||||||||||||||
Asian | 6 | 1.32(1.15–1.50) | 0.0 | 0.641 | 1.11(0.82–1.48) | 23.8 | 0.255 | 1.54(1.14–2.09) | 0.0 | 0.407 | 1.32(0.98–1.76) | 4.3 | 0.389 | 1.48(1.24–1.77) | 0.0 | 0.507 |
Caucasian | 4 | 1.08(0.83–1.40) | 53.7 | 0.091 | 0.89(0.65–1.22) | 0.0 | 0.439 | 1.01(0.71–1.43) | 50.8 | 0.107 | 0.93(0.69–1.24) | 31.0 | 0.226 | 1.14(0.88–1.48) | 31.2 | 0.225 |
Cancer type | ||||||||||||||||
LC | 3 | 1.36(1.17–1.59) | 0.0 | 0.398 | 1.43(1.01–2.03) | 16.2 | 0.303 | 1.93(1.36–2.75) | 36.8 | 0.206 | 1.65(1.18–2.30) | 32.0 | 0.230 | 1.45(1.18–1.79) | 0.0 | 0.655 |
PC | 2 | 1.20(0.89–1.62) | 63.2 | 0.099 | 0.61(0.33–1.11) | 0.0 | 0.587 | 1.00(0.53–1.85) | 0.0 | 0.509 | 0.78(0.44–1.38) | 0.0 | 0.872 | 1.58(0.76–3.28) | 67.8 | 0.078 |
others | 5 | 0.97(0.83–1.15) | 7.3 | 0.362 | 0.80(0.60–1.07) | 0.0 | 0.868 | 0.95(0.67–1.35) | 0.0 | 0.762 | 0.83(0.63–1.10) | 0.0 | 0.968 | 1.16(0.91–1.49) | 14.5 | 0.322 |
Genotyping method | ||||||||||||||||
PCR–RFLP | 6 | 1.25(1.06–1.48) | 14.2 | 0.323 | 1.09(0.77–1.54) | 22.8 | 0.263 | 1.48(1.04–2.10) | 38.3 | 0.151 | 1.23(0.89–1.71) | 37.8 | 0.154 | 1.40(1.11–1.76) | 0.0 | 0.784 |
others | 4 | 1.08(0.80–1.46) | 65.2 | 0.013 | 0.89(0.68–1.16) | 12.5 | 0.330 | 1.17(0.87–1.57) | 41.9 | 0.160 | 0.97(0.75–1.24) | 20.9 | 0.285 | 1.31(0.86–2.00) | 65.8 | 0.034 |
Source of control | ||||||||||||||||
HB | 6 | 1.11(0.95–1.29) | 52.1 | 0.064 | 0.80(0.60–1.05) | 0.0 | 0.397 | 1.02(0.74–1.42) | 22.9 | 0.258 | 0.86(0.66–1.12) | 0.0 | 0.309 | 1.29(1.02–1.63) | 49.5 | 0.078 |
PB | 4 | 1.28(1.11–1.48) | 0.0 | 0.461 | 1.22(0.88–1.68) | 14.9 | 0.317 | 1.61(1.17–2.23) | 27.5 | 0.247 | 1.39(1.03–1.89) | 27.2 | 0.249 | 1.38(1.14–1.68) | 0.0 | 0.749 |
Score ≥ 10 | 8 | 1.23(1.05–1.45) | 46.8 | 0.069 | 1.03(0.82–1.30) | 24.6 | 0.233 | 1.35(1.06–1.71) | 34.6 | 0.178 | 1.15(0.93–1.42) | 37.7 | 0.129 | 1.36(1.17–1.59) | 29.1 | 0.191 |