Association between IL-18 polymorphisms, serum levels, and HBV-related hepatocellular carcinoma in a Chinese population: a retrospective case–control study

Table 5 The association between IL-18 gene polymorphisms and serum IL-18 levels (median ± interquartile range, ng/L) in HCC patients

Groups	Overall	−607C/A (rs1946518)				−137G/C (rs187238)
Groups	Overall	AA	AC	CC	P value^a	GG	GC	CC	P value^a
Controls (n = 165)	112.48 ± 68.65	108.63 ± 105.14 (41)	107.49 ± 71.25 (76)	118.54 ± 46.25 (48)	0.514	118.54 ± 66.47 (106)	101.18 ± 63.20 (54)	108.06 ± 99.24 (5)	0.186
HCC (n = 153)	74.40 ± 45.20	77.48 ± 50.58 (37)	76.33 ± 42.60 (73)	67.10 ± 43.85 (43)	0.202	74.69 ± 47.75 (128)	69.21 ± 36.3 (28)	71.33 ± 52.89 (3)	0.942
P value^b	<0.000	0.002	<0.000	<0.000		<0.000	<0.000	0.549

^aKruskal–Wallis test: comparing the difference of serum IL-18 levels in different genotypes among the same group subjects.
^bMann–Whitney U-test: comparing the difference of serum IL-18 levels between the two group subjects among individuals with the same genotype.

ISSN: 1475-2867