Effects of the aqueous extract of a Tibetan herb, Rhodiola algida var. tangutica on proliferation and HIF-1α, HIF-2α expression in MCF-7 cells under hypoxic condition in vitro

Table 2 Effect of Rhodiola algida Var. tangutica on proliferation of MCF-7 breast cancer cells exposed to normoxia and hypoxia for 48 h (absorbance at 490 nm, A490)

Rhodiola algida var. tangutica	0 μg/mL	45 μg/mL	90 μg/mL	180 μg/mL	225 μg/mL	360 μg/mL	450 μg/mL
N48 h	0.301 ± 0.070	0.296 ± 0.059	0.284 ± 0.067	0.273 ± 0.058	0.265 ± 0.043	0.247 ± 0.045^a	0.239 ± 0.062^a
H48 h	0.358 ± 0.048	0.346 ± 0.054	0.327 ± 0.078	0.314 ± 0.057	0.308 ± 0.071^b	0.274 ± 0.067^b	0.266 ± 0.074^b

The data represented mean ± S.D. (n = 9). N48 h indicates exposure to normoxia for 48 h; H48 h, exposure to hypoxia for 48 h.
^aP < 0.05 vs. N48 h in the absence of Rhodiola algida var. tangutica.
^bP < 0.05 vs. H48 h in the absence of Rhodiola algida var. tangutica.

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