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Table 2 Calculated bupivacaine concentration (ppm) with 50% cell survival (IC50)

From: In vitro myotoxic effects of bupivacaine on rhabdomyosarcoma cells, immortalized and primary muscle cells

Incubation/recovery time (h)

Differentiated primary muscle cells [IC50 ± SD] (ppm)

Rhabdomyosarcoma cells [IC50 ± SD] (ppm)

Immortalized C2C12 cells [IC50 ± SD] (ppm)

1/24

1,232 ± 421

2,400 ± 703

3,814 ± 1,104

1/48

1,472 ± 438

1,908 ± 658

3,436 ± 1,266

2/24

834 ± 300

1,958 ± 620

2,413 ± 840

2/48

1,132 ± 442

1,871 ± 598

2,526 ± 826