Fig. 5From: Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cellsMechanisms of anti-tumor activity of PA in vivo. a–e PA was administered for 3 weeks by ip injection to nude mice bearing NCI-H23 xenograft tumors. At the end of the experiments, tumors were excised and processed for H&E staining (a), immunostaining and quantification for Ki-67 (b), TUNEL (c), p-JNK (d) and CHOP (e). Scale bars are 100 μm.Back to article page