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Fig. 7 | Cancer Cell International

Fig. 7

From: PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells

Fig. 7

Schematic pathway alternations of MK-2206 resistance. a Signal pathway study of MK-2206 non-resistant cells showed that AKT acted in mTOR-S6K dependent method (LAN-1 and SK-N-DZ), in which inhibition of AKT reduced activity of mTOR-S6K signaling. Activity of PDK1 took the place of AKT, and elevated PDK1-mTOR-S6K transduction contributed to MK-2206 resistance, when AKT-mTOR-S6K was blocked. b AKT acted in mTOR-S6K independent method (KP-N-SIFA and NB-19), in which inhibition of AKT did not impair the activity of mTOR-S6K signaling. Parallel signaling pathway of PDK1-MTOR-S6K became an important alternative for cell growth of MK-2206-resistant sublines, when AKT was inhibited. And some other signal pathway may contribute to MK-2206 resistance as well

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