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Table 1 The estimated 50 % inhibitory concentration (IC50) of different CLN isomers for PU5-1.8 cells

From: Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis

CLN isomer

IC50 (µM) at 48 h

α-Calendic acid (8E, 10E, 12Z-octadecatrienoic acid)

12.11 ± 1.35

β-Calendic acid (8E, 10E, 12E-octadecatrienoic acid)

29.69 ± 4.04

Jacaric acid (8Z, 10E, 12Z-octadecatrienoic acid)

6.00 ± 0.87

α-Eleostearic acid (9Z, 11E, 13E-octadecatrienoic acid)

10.74 ± 1.33

β-Eleostearic acid (9E, 11E, 13E-octadecatrienoic acid)

9.57 ± 0.75

Punicic acid (9Z, 11E, 13Z-octadecatrienoic acid)

8.40 ± 1.48

  1. The IC50 value is the concentration of CLN isomer that inhibits the proliferation of the murine leukemia PU5-1.8 cells by 50 % after 48-h treatment
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Cancer Cell International

ISSN: 1475-2867

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