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Table 1 Validated targets for miR cluster 143/145 with their cancer-related function

From: Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis

Target genes

Type of cancer

Cancer-related function

References

miR-143

KRAS

CRC, PCa, PaCa

Proliferation

[109]

MACC1

CRC

Metastasis

[110]

TLR2

CRC

Proliferation, invasion

[109]

DNMT3A

CRC, BrCa, leukemia

Proliferation

[111–113]

Akt

CRC, BC, HCC, glioma

Apoptosis, proliferation

[114–117]

ERK5

CRC, PCa, BC, B-cell malignancy

Proliferation

[115, 117–119]

Bcl2

CRC, BrCa, OC, BC

Apoptosis

[60, 92, 115, 120]

Survivin

BrCa

Apoptosis

[89]

ARHGEF1

PaCa

Metastasis

[92]

ARHGEF2

PaCa

Proliferation, invasion

[121]

FNDC3B

HCC

Metastasis

[121]

Cox2

BC, GC

Metastasis

[117, 131]

MMP-13

OC, lung

Invasion

[122, 123]

Lmk1

Lung

Metastasis

[124]

miR-145

Cateninδ-1

CRC

Proliferation, invasion

[125]

DFF45

CRC

Apoptosis

[126]

VEGF

CRC, BrCa, OC, thyroid, GB

Angiogenesis

[127–130]

c-Myc

CRC, PCa, EOC, BrCa, PaCa, ESCC, lung, glioma, RCC

Proliferation, invasion, apoptosis

[58, 131–134]

PAK4

CRC

Proliferation, invasion

[135]

IRS1

CRC, HCC, BC

Proliferation

[49]

IRS2

CRC

Proliferation

[84]

YES

CRC

Proliferation

[136]

STAT1

CRC

Proliferation

[136]

Fascin-1

CRC, BrCa, BC, ESCC, glioma

Invasion

[106, 137–140]

SWAP70

PCa

Invasion

[141]

ERG

PCa

Proliferation, invasion, apoptosis, angiogenesis

[142]

CD44

PCa, lung

CSC

[132, 134, 143]

Oct4

PCa, lung, GCT

CSC

[132]

KLF4

PCa, GCT

CSC

[144]

CDK4

Lung

Proliferation

[145]

CDK6

EOC, OSCC

Proliferation

[146]

p70S6K1

CRC, EOC

Proliferation

[146]

Muc-1

EOC, BrCa

Invasion

[146, 147]

RTKN

BrCa

Proliferation, invasion

[148, 149]

JAM-A

BrCa

Proliferation

[150]

ERα

BrCa

Proliferation

[83]

RREB1

PaCa

Proliferation, apoptosis

[74]

HDAC2

HCC

Transcriptional regulation

[103]

Ets1

GC

Migration, apoptosis, angiogenesis

[151]

N-cadherin

GC

Invasion

[152]

E-cadherin

Thyroid

Invasion

[130]

EGFR

Lung, glioma

Proliferation

[153, 154]

NUDT1

BC, lung

Proliferation

[153]

ROCK1

OC, glioma

Proliferation, migration

[155, 156]

FLT1

OC

Proliferation

[157]

PAK1

BC

Proliferation, metastasis

[158]

CBFβ

BC

Apoptosis

[159]

PPP3CA

BC

Apoptosis

[159]

CLINT1

BC

Apoptosis

[159]

SOCS7

BC

Apoptosis

[160]

Ilk

BC

Cell division/proliferation

[161]

ANGPT2

RCC

Angiogenesis

[40]

NEDD9

Glioma, RCC

Proliferation, metastasis

[40, 98]

MMP-11

RCC

Metastasis

[162]

CTGF

Glioma

Proliferation, invasion, metastasis, angiogenesis

[104]

ADAM17

Glioma, RCC, HNSCC

Proliferation, invasion, metastasis, angiogenesis

[96]

ADAM22

Glioma

Metastasis, drug resistance

[106]

Abcg2

Glioma

Drug resistance, CSC

[51]

ADD3

Glioma

Proliferation, invasion

[70]

Sox9

Glioma, HNSCC

Proliferation, CSC

[70, 72]

Sox2

Glioma, GCT

Proliferation, CSC

[97, 163]

Nanog

Glioblastoma

CSC

[97]

PLAUR

Glioblastoma

Metastasis

[106]

SPOCK3

Glioma

Invasion

[106]

SLC7A5

Glioma

Proliferation, metastasis

[106]

AKT3

Thyroid

Metastasis

[205]

miR-143 and miR-145

KLF5

CRC

Proliferation

[61]

Myo6

PCa

Migration, apoptosis

[164]

GOLM1

PCa

Metastasis

[165]

CD133

PCa

CSC

[132]

IGFIR

CRC, HCC, BC

Proliferation

[114, 166, 167]

MDM2

BrCa, HNSCC

Apoptosis

[65]

PAI-1

BC

Migration, metastasis

[168]

HK2

BrCa, HNSCC, OC, RCC, glioma

Tumor initiation and maintenance

[42, 86, 169–172]

N-ras

BrCa, glioma

Cell division, proliferation, apoptosis

[117, 128, 173, 174]

ERBB3

BrCa

Drug resistance

[175]

  1. CRC colorectal cancer, PCa prostate cancer, PaCa pancreatic cancer, BrCa breast cancer, GC gastric cancer, HCC hepatocellular carcinoma, OC osteosarcoma, RCC renal cell carcinoma, BC bladder cancer, HNSCC head and neck squamous cell carcinoma, GCT germ cell tumor, OSCC oral squamous cell carcinoma, GB gall bladder, EOC epithelial ovarian cancer, ESCC esophageal squamous cell carcinoma