Fig. 4
From: STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7
Effect of STAT1 on cyclin A, cyclin D1, cyclin E and CDK2. a, b, c, d, e Western blot was used to analyze cyclin A, cyclin D1, cyclin E, and CDK2 protein expression. Actin served as internal control. Cyclin A, cyclin D1, cyclin E, and CDK2 expression levels were significantly decreased in STAT1-transfected SMMC7721 and HepG2 cells compared to SMMC7721, HepG2 and EV cells (P < 0.05); f, g, h, i, j cyclin A, cyclin D1, cyclin E, and CDK2 protein were analyzed by western blot in STAT1 siRNA2, control siRNA, SMMC7721 and HepG2 cells. Cyclin A, cyclin D1, cyclin E and CDK2 expression levels were increased in STAT1 siRNA2 cells when compared with control siRNA, SMMC7721 and HepG2 cells (P < 0.05)