Dimethylsulfoxide excerbates cisplatin-induced cytotoxicity in Ehrlich ascites carcinoma cells

Table 2 Average weights and tumor inhibition of ehrlich solid tumor 18 days after treatment

Ehrlich ascites carcinoma cells were injected intramuscularly in right thigh of female Swiss albino mice The next day, animals were randomized and divided into four groups each treatment group contains 10 animals. Group I injected with normal saline (2 ml/kg, i.p.) and served as control group. Group II treated with 50 % DMSO (2 ml/kg, i.p.). Group III treated with cisplatin (4.5 mg/kg, i.p.). Group IV treated with (2 ml/kg, i.p.) of 50 % DMSO followed by cisplatin (4.5 mg/kg, i.p.) 2 h later. Each data represent the mean ± SEM
^aSignificantly different from normal saline treated group at P value <0.05
^bSignificantly different from cisplatin treated group at P value <0.05

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