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Table 3 Effect of DMSO pretreatment on the cellular uptake of cisplatin in EAC cells using ICP-MS

From: Dimethylsulfoxide excerbates cisplatin-induced cytotoxicity in Ehrlich ascites carcinoma cells

Cisplatin concentration (ng/106 cells)

 

6 h after treatment

24 h after treatment

48 h after treatment

Cisplatin (4.5 mg/kg)

7 ± 0.26

14 ± 0.47

18 ± 0.58

Cisplatin (4.5 mg/kg) and 50 % DMSO (2 ml/kg)

15 ± 0.23 a

28 ± 0.45a

35 ± 1.25a

  1. Cisplatin was injected (4.5 mg/kg, i.p.) in tumor-bearing mice pretreated with DMSO (2 ml/kg, i.p.) or saline. After 6, 24 and 48 h of treatment, cells were withdrawn and washed twice with PBS, counted then digested by using 1 % nitric acid. Data are expressed as mean ± S.E.M (n = 10)
  2. aSignificantly different from corresponding CIS at P value <0.05