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Table 3 Results of the Human Breast Cancer & Estrogen Receptor Signaling RT2 PCR Array experiment

From: Morphological and molecular characterization of the human breast epithelial cell line M13SV1 and its tumorigenic derivatives M13SV1-R2-2 and M13SV1-R2-N1

Gene name

Gene symbol

R2-2 vs. M13SV1

R2-N1 vs. M13SV1

Fold regulation

p-value

Fold regulation

p-value

Androgen receptor

AR

4.59

0.096

4.48

0.230

BCL2-associated agonist of cell death

BAD

−1.20

0.723

1.26

0.675

BCL2-associated athanogene

BAG1

−1.18

0.545

−1.39

0.043

B-cell CLL/lymphoma 2

BCL2

−1.62

0.197

−2.65

0.088

BCL2-like 2

BCL2L2

1.02

0.914

1.94

0.246

Complement component 3

C3

1.17

0.733

1.14

0.890

Cyclin A1

CCNA1

−2.32

0.009

1.72

0.010

Cyclin A2

CCNA2

1.53

0.069

1.25

0.489

Cyclin D1

CCND1

1.26

0.879

1.13

0.836

Cyclin E1

CCNE1

1.69

0.078

2.11

0.038

CD44 molecule (Indian blood group)

CD44

1.20

0.740

1.30

0.572

Cadherin 1, type 1, E-cadherin (epithelial)

CDH1

1.29

0.493

1.29

0.537

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A

−1.84

0.004

1.39

0.190

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

CDKN1B

1.52

0.286

−1.08

0.764

Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

CDKN2A

−1.15

0.056

−1.08

0.998

Claudin 7

CLDN7

1.29

0.671

−1.19

0.713

Clusterin

CLU

2.24

0.109

−1.41

0.336

Collagen, type VI, alpha 1

COL6A1

1.60

0.346

4.49

0.010

Catenin (cadherin-associated protein), beta 1, 88 kDa

CTNNB1

2.36

0.139

1.94

0.393

Cathepsin B

CTSB

−1.05

0.817

1.46

0.155

Cathepsin D

CTSD

1.59

0.178

1.04

0.876

Cytochrome P450, family 19, subfamily A, polypeptide 1

CYP19A1

1.06

0.836

1.91

0.154

Deleted in liver cancer 1

DLC1

1.37

0.564

−1.48

0.370

Epidermal growth factor receptor

EGFR

1.41

0.421

1.04

0.986

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

ERBB2

2.03

0.355

8.15

0.062

Estrogen receptor 1

ESR1

1.59

0.217

−1.60

0.256

Estrogen receptor 2 (ER beta)

ESR2

1.69

0.298

2.10

0.166

Fas (TNF receptor superfamily, member 6)

FAS

−1.06

0.681

−1.16

0.499

Fas ligand (TNF superfamily, member 6)

FASLG

1.38

0.301

1.47

0.109

Fibroblast growth factor 1 (acidic)

FGF1

1.14

0.801

2.94

0.084

Fibronectin leucine rich transmembrane protein 1

FLRT1

1.13

0.483

1.83

0.196

FOS-like antigen 1

FOSL1

−1.14

0.546

1.51

0.192

Gamma-aminobutyric acid (GABA) A receptor, pi

GABRP

2.64

0.138

1.27

0.511

GATA binding protein 3

GATA3

−1.23

0.550

−2.70

0.092

GNAS complex locus

GNAS

1.07

0.827

1.23

0.832

Gelsolin

GSN

−1.09

0.904

1.14

0.731

High mobility group box 1

HMGB1

−1.09

0.455

1.18

0.402

Heat shock 27 kDa protein 1

HSPB1

1.53

0.042

1.16

0.533

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

ID2

−1.09

0.677

−1.46

0.380

Insulin-like growth factor binding protein 2, 36 kDa

IGFBP2

1.06

0.794

−3.35

0.262

Interleukin 2 receptor, alpha

IL2RA

1.16

0.404

1.48

0.109

Interleukin 6 (interferon, beta 2)

IL6

−1.99

0.114

1.07

0.884

Interleukin 6 receptor

IL6R

1.49

0.006

1.50

0.145

Interleukin 6 signal transducer (gp130, oncostatin M receptor)

IL6ST

1.62

0.266

1.35

0.547

Integrin, alpha 6

ITGA6

−1.07

0.600

1.17

0.505

Integrin, beta 4

ITGB4

1.20

0.812

−1.02

0.824

Jun proto-oncogene

JUN

1.05

0.997

1.02

0.686

V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

KIT

4.73

0.044

4.81

0.233

Kruppel-like factor 5 (intestinal)

KLF5

−1.37

0.301

−1.29

0.399

Kallikrein-related peptidase 5

KLK5

−1.80

0.241

−1.41

0.431

Keratin 18

KRT18

1.48

0.026

1.36

0.042

Keratin 19

KRT19

2.30

0.031

1.87

0.146

Mitogen-activated protein kinase kinase 7

MAP2K7

2.40

0.121

1.58

0.515

Antigen identified by monoclonal antibody Ki-67

MKI67

1.48

0.029

1.19

0.362

Metallothionein 3

MT3

−2.40

0.310

−1.48

0.828

Mucin 1, cell surface associated

MUC1

−1.30

0.540

−1.72

0.289

Nuclear transcription factor Y, beta

NFYB

1.26

0.571

1.20

0.746

Nerve growth factor (beta polypeptide)

NGF

1.17

0.501

1.16

0.484

Nerve growth factor receptor

NGFR

1.53

0.633

2.61

0.173

Non-metastatic cells 1, protein (NM23A) expressed in

NME1

1.21

0.345

1.31

0.300

Pregnancy-associated plasma protein A, pappalysin 1

PAPPA

−1.03

0.682

−2.57

0.085

Progesterone receptor

PGR

−1.06

0.684

−4.92

0.163

Plasminogen activator, urokinase

PLAU

1.16

0.672

1.66

0.113

Phosphatase and tensin homolog

PTEN

−1.13

0.797

1.05

0.735

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

PTGS2

−1.90

0.157

−3.64

0.104

Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

RAC2

1.71

0.039

2.11

0.052

Ribosomal protein L27

RPL27

−1.02

0.767

1.16

0.254

Secretoglobin, family 1D, member 2

SCGB1D2

1.12

0.697

1.29

0.439

Secretoglobin, family 2A, member 1

SCGB2A1

−2.02

0.084

−1.78

0.142

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

SERPINA3

10.61

0.008

16.47

0.201

Serpin peptidase inhibitor, clade B (ovalbumin), member 5

SERPINB5

−1.25

0.028

−1.12

0.448

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPINE1

−1.31

0.206

−1.55

0.434

Solute carrier family 7 (amino acid transporter light chain, L system), member 5

SLC7A5

1.52

0.505

-1.08

0.910

Small proline-rich protein 1B

SPRR1B

−1.13

0.703

−1.32

0.363

Stanniocalcin 2

STC2

−1.42

0.038

−1.23

0.562

Trefoil factor 1

TFF1

−9.16

0.005

1.04

0.858

Transforming growth factor, alpha

TGFA

−1.26

0.376

−1.37

0.387

Thrombospondin 1

THBS1

1.01

0.995

−1.49

0.122

Thrombospondin 2

THBS2

−1.09

0.602

5.09

0.008

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1

TIE1

1.08

0.836

2.10

0.153

Tumor necrosis factor, alpha-induced protein 2

TNFAIP2

1.09

0.782

−1.05

0.921

Topoisomerase (DNA) II alpha 170 kDa

TOP2A

1.75

0.048

1.25

0.526

Tumor protein p53

TP53

1.19

0.690

1.14

0.786

Vascular endothelial growth factor A

VEGFA

1.09

0.588

−1.12

0.785