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Fig. 6 | Cancer Cell International

Fig. 6

From: ESC reverses epithelial mesenchymal transition induced by transforming growth factor-β via inhibition of Smad signal pathway in HepG2 liver cancer cells

Fig. 6

ESC inhibited TGF-β-induced Smad signaling pathway. a Pretreatment with 5 μg/mL ESC for 2 h significantly suppressed the expression of phosphorylation of Smad2 induced by TGF-β for 0.5–6 h, but no influence on expression of Smad2. b Pretreatment of 5 μg/mL ESC for 2 h could inhibit the nucleus translocation induced by TGF-β in hepG2 cells. The magnification is 200 times. c 5 μg/mL ESC and 25 μM SB432542 significantly reversed EMT proteins induced by TGF-β, inhibiting expression of phosphorylation of Smad2 and Vimentin, enhancing expression of E-cadherin and the coordination of ESC and SB432542 was showed. d 5 μg/mL ESC and 25 μM SB432542 could inhibited cell migration and invasion induced by TGF-β and also showed coordination effects

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Cancer Cell International

ISSN: 1475-2867

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