Fig. 5
Effect of As2O3 (1 µM) on chemo-sensitivity, MMP, and cell cycle of HBx-HepG2 cells pretreated with hypoxia (1 % O2). MTT assay was used to evaluate the effect of As2O3 on chemo-sensitivity to a 5-FU (50–1600 µM) or b cisplatin (25–800 µM) in HBx-HepG2 cells pretreated with 48 h hypoxia (1 % O2); c flow-cytometry was used to examine the effect of As2O3 on MMP in HBx-HepG2 cells pretreated with 48 h hypoxia (1 % O2); d flow-cytometry was used to examine the effect of As2O3 on MMP in HBx-HepG2 cells pretreated with 48 h hypoxia (1 % O2). All data were expressed as mean ± s.e.m., n = 4; ATO = As2O3; significant differences between hypoxia (1 % O2) group and hypoxia (1 % O2) + ATO group were indicated as *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired t-test)