|
Compound
|
Conc. [M]
|
Inhibition indexa (%) (control = 100 %)
|
|---|
|
A2058
|
HT168-M1
|
MRC-5
|
|---|
|
Alizarin
|
10−6
|
98.3 ± 1.52
|
98.3 ± 1.46
|
98.4 ± 1.62
|
|
10−5
|
103.8 ± 1.30
|
96.5 ± 1.61
|
104.6 ± 1.86
|
|
Purpurin
|
10−6
|
100.0 ± 1.45
|
100.8 ± 1.55
|
99.1 ± 1.12
|
|
10−5
|
90.6*** ± 1.09
|
87.0*** ± 1.79
|
103.16 ± 2.14
|
|
Aqueous extract
|
10−6
|
93.3* ± 0.86
|
101.9 ± 1.24
|
102.7 ± 1.52
|
|
10−5
|
84.5*** ± 1.06
|
116.1*** ± 1.39
|
100.3 ± 1.17
|
- Two different melanoma cell lines (A2058 and HT168-M1) and normal fibroblast cells (MRC-5) were applied as model cells and were incubated with the anthraquinones for 6 h
- The ‘Inhibition index’ is expressed as a percentage of the control. Data shown in the table represent mathematical averages of six parallels and ± S.D. values
- The level of significance is shown as follows: * p < 0.05; *** p < 0.001
