Skip to main content

Table 2 Adhesion modulator effect of the alizarin, purpurin and the aqueous extract

From: Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1)

Compound

Conc. [M]

Slopea (%) (control = 100 %)

A2058

HT168-M1

MRC-5

Alizarin

10−8

88.9 ± 6.74

100.4 ± 3.05

99.3 ± 4.96

10−7

100.6 ± 4.01

104.3 ± 3.16

104.7 ± 0.82

10−6

110.8 ± 6.38

110.4 ± 1.37

100.2 ± 2.44

10−5

90.4 ± 8.7

107.3 ± 6.51

95.5 ± 7.08

Purpurin

10−8

85.6 ± 4.36

93.6 ± 4.91

102.1 ± 5.44

10−7

97.6 ± 1.86

101.0 ± 3.42

103.7 ± 2.22

10−6

95.2 ± 14.01

97.8 ± 15.16

109.6 ± 2.4

10−5

115.6 ± 6.56

110.2 ± 4.03

93.8 ± 5.14

Aqueous extract

10−8

99.3 ± 4.96

102.1 ± 5.44

105.4 ± 1.64

10−7

104.7 ± 0.82

103.7 ± 2.22

104.5 ± 1.99

10−6

100.2 ± 2.44

109.6 ± 2.4

98.4 ± 4.25

10−5

95.5 ± 7.08

93.8 ± 5.14

91.7* ± 2.58

  1. Two different melanoma cell lines (HT168-M1) and normal fibroblast cells (MRC-5) were applied as model cells
  2. Data shown in the table represent mathematical averages of three parallels and ± S.D. values
  3. The level of significance is shown as follows: * p < 0.05
  4. aThe slope values are expressed in percentage of the control and describe the changing rate of Delta CI in first 3 h’ time interval of cell adhesion
Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us