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Table 2 Adhesion modulator effect of the alizarin, purpurin and the aqueous extract

From: Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1)

Compound Conc. [M] Slopea (%) (control = 100 %)
A2058 HT168-M1 MRC-5
Alizarin 10−8 88.9 ± 6.74 100.4 ± 3.05 99.3 ± 4.96
10−7 100.6 ± 4.01 104.3 ± 3.16 104.7 ± 0.82
10−6 110.8 ± 6.38 110.4 ± 1.37 100.2 ± 2.44
10−5 90.4 ± 8.7 107.3 ± 6.51 95.5 ± 7.08
Purpurin 10−8 85.6 ± 4.36 93.6 ± 4.91 102.1 ± 5.44
10−7 97.6 ± 1.86 101.0 ± 3.42 103.7 ± 2.22
10−6 95.2 ± 14.01 97.8 ± 15.16 109.6 ± 2.4
10−5 115.6 ± 6.56 110.2 ± 4.03 93.8 ± 5.14
Aqueous extract 10−8 99.3 ± 4.96 102.1 ± 5.44 105.4 ± 1.64
10−7 104.7 ± 0.82 103.7 ± 2.22 104.5 ± 1.99
10−6 100.2 ± 2.44 109.6 ± 2.4 98.4 ± 4.25
10−5 95.5 ± 7.08 93.8 ± 5.14 91.7* ± 2.58
  1. Two different melanoma cell lines (HT168-M1) and normal fibroblast cells (MRC-5) were applied as model cells
  2. Data shown in the table represent mathematical averages of three parallels and ± S.D. values
  3. The level of significance is shown as follows: * p < 0.05
  4. aThe slope values are expressed in percentage of the control and describe the changing rate of Delta CI in first 3 h’ time interval of cell adhesion