Treatment with G-CSF reduces acute myeloid leukemia blast viability in the presence of bone marrow stroma

Nomdedeu, Meritxell; Lara-Castillo, María Carmen; Etxabe, Amaia; Cornet-Masana, Josep María; Pratcorona, Marta; Díaz-Beyá, Marina; Calvo, Xavier; Rozman, María; Costa, Dolors; Esteve, Jordi; Risueño, Ruth M.

doi:10.1186/s12935-015-0272-3

Cancer Cell International

Table 1 AML patients’ characteristics

From: Treatment with G-CSF reduces acute myeloid leukemia blast viability in the presence of bone marrow stroma

AML sample	Gender	Age (yo)	WHO 2008 category	Karyotype	NPM1,FLT3-ITD, CEBPA and DNMT3A mutational status	Chemosensitivity
#1	M	28	AML NOS, without maturation	46, XY	FLT3 ITD	CS
#2	M	40	AML with mutated CEBPA	46, XY	CEBPA^mut
#3	F	34	AML with myelodysplasia-related changes	45, XX, −7	FLT3 ITD^neg, NPM1^wt	CR
#4	M	45	AML with t(6,9)(p23;q34);DEK-NUP214	46, XY, t(6;9)(p23;q34)	FLT3 ITD	CS
#6	M	61	AML with t(8;21)(q22;q22); RUNX1-RUNX1T1	45, X–Y, t(8;21)(q22;q22)[19]/46, XY	FLT3 ITD^neg, NPM1^wt	CS
#7	F	58	AML with myelodysplasia-related changes	46, XX, del(5)(q23q33), t(8;9)(p11;q34)	FLT3 ITD^neg, NPM1^wt
#8	M	24	AML with myelodysplasia-related changes	46, XY	FLT3 ITD^neg, NPM1^wt
#9	M	49	AML with myelodysplasia-related changes	Complex karyotype	FLT3 ITD^neg, NPM1^wt
#10	F	66	AML with myelodysplasia-related changes	46, XX, del(11)(q22q23)	FLT3 ITD
#11	M	22	AML with t(8;21)(q22;q22); RUNX1-RUNX1T1	45, X, −Y, t(8;21)(q22;q22)/46, XY	FLT3 ITD	CS
#12	F	22	AML with inv(16)(p13.1q22);CBFB-MYH11	46, XX, inv(16)(p13q22)/46, XX	FLT3 ITD^neg, NPM1^wt
#13	M	37	AML with mutated NPM1	46, XY	NPM1^mut, DNMT3A^mut
#14	M	42	AML with mutated NPM1	46, XY	NPM1^mut, FLT3 ITD
#15	F	60	AML with myelodysplasia-related changes	48, XX, +8, +21	FLT3 ITD^neg, NPM1^wt
#16	F	62	AML NOS, with maturation	46, XX	FLT3 ITD^neg, NPM1^wt
#17	F	60	AML with myelodysplasia-related changes	Complex karyotype	FLT3 ITD^neg, NPM1^wt
#18	F	55	AML with inv(16)(p13.1q22);CBFB-MYH11	46, XX, inv(16)(p13q22)/46, XX	FLT3 ITD^neg, NPM1^wt
#19	M	63	AML with myelodysplasia-related changes	46, XY	FLT3 ITD	CR
#20	M	61	AML with mutated NPM1	46, XY	NPM1^mut, DNMT3A^mut	CR
#21	F	51	AML NOS, acute monoblastic leukemia	Not available	NPM1^mut, FLT3 ITD^neg
#22	F	36	AML with mutated NPM1	46, XX	NPM1^mut, FLT3 ITD^neg

M male, F female, yo years old, FLT3-ITD FLT3 internal tandem duplication, CEBPA ^mut biallelic CEBPA mutation, FLT3 ITD ^neg absence of FLT3-ITD, NPM1wt wild-type NPM1, NPM1 ^mut mutated NPM1, Wt wildtype

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ISSN: 1475-2867

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