Fig. 1

Cydonia oblonga Miller polyphenolic extract reduces LS174 cell viability in a dose-dependent manner. a Non-tumourigenic cells HEK293, NIH 3T3 and Human colon adenocarcinoma LS174 cells were treated for 72 h with increasing concentrations (1–20 µg/ml) of Cydonia oblonga Miller peel (Peph) and pulp (Puph) polyphenolic extract. Cell viability was determined by MTT assay. b LDH release from HEK293, NIH 3T3 and LS174 cells was determined by using the LDH assay after 72 h of treatment with different concentrations (5–20 µg/ml) of Peph and Puph. Results were normalized to each control in percentage and represented as mean ± SE of three independent experiments, each performed at least in triplicate. Statistical differences were analyzed with Student’s t test (*p < 0.05 as compared to the control, ns: non significant)