Fig. 1

Densities of cancer somatic mutations of ccRCC associated to a wide range of genomic features chromosome by chromosome. For each chromosome, the size of each feature was calculated and numbers of somatic mutations were counted, somatic mutation densities were computed. The red and blue dashed lines stand for CDS and genome-wide average mutation densities. CDS coding sequence, CR conserved region, ECS evolutionarily conserved structure, GCH and GCL 1 Kb-windows with high and low GC content, Exon.P and Exon.L, Intron.P and Intron.P exon and intron of protein coding gene and lncRNA respectively, PCgene protein coding gene, cTFBS conserved TFBS, UTR Untranslated region, PCgene.ER and PCgene.LR, LncRNA.ER and LncRNA.LR early and late replicated protein coding gene and lncRNA, PCgene.HE and PCgene.LE, LncRNA.HE and LncRNA.LE high and low expressed protein coding gene and lncRNA, RRH and RRL 1 Kb-windows with high and low recombination rate, H3K4me1, H3K9ac, etc. histone methylation and acetylation data, ncExon non coding Exon