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Table 3 Elevation of adenylate energy charge (AEC) by glucose and acetate in starving tumour cell cultures

From: Characterisation of bioenergetic pathways and related regulators by multiple assays in human tumour cells

 

Adenylate energy charge (AEC*) value

ZR-75.1 mammary adenocarcinoma (A)

HT-1080 fibrosarcoma (B)

D5030 medium

0.54 ± 0.15 (100 %)

0.38 ± 0.10 (100 %)

D5030 medium + glucose

0.61 ± 0.15 (113 %)

0.64 ± 0.18 (168 %)*

D5030 medium + acetate

0.69 ± 0.094 (128 %)*

0.46 ± 0.16 (121 %)

  1. \({\text{AEC}} = \frac{{{\text{ATP}} + {1 \mathord{\left/ {\vphantom {1 2}} \right. \kern-0pt} 2}{\text{ADP}}}}{{{\text{ATP}} + {\text{ADP}} + {\text{AMP}}}}\)
  2. Data from three independent measurements and 3 parallel samples
  3. * p < 0.05
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Cancer Cell International

ISSN: 1475-2867

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