Fig. 8

Promoter methylation of DOK 7 and ELF5 in primary (1°) and second or recurrent (2°) breast tumors by PR status of three groups of women: women who had a primary PR-positive tumor and a second PR-positive tumor (n = 10, gray boxes); women who had a primary PR-positive tumor and a second PR-negative tumor (n = 6; white boxes); and women who had a primary PR-negative tumor and a second PR-negative tumor (n = 8; yellow boxes) Average beta distribution analysis of 9 CpG sites in the TSS of DOK7 (top) and 8 CpGs sites in the TSS of ELF5 (bottom). Box is quartile 1 and 3; red line is median average β value, whiskers are the highest and lowest values within ×1.5 interquartile range