Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells

Table 1 The mass-action law parameters for fisetin and/or paclitaxel in A549 cells

Compound	M	D_m	r	n
FIS	1.69	74.88	0.99	5
PTX	0.36	9.63	0.99	5
FIS + PTX	0.63	10.87	0.99	5

The data obtained from MTT assays were subjected to automated calculation of m, Dm (µM) and r parameters using CompuSyn software. The parameters m, D_m, and r are the slope, the median-effect dose, and the linear correlation coefficient of the median-effect plot, which signify the shape of the dose–effect curve, the potency (IC₅₀), and the conformity of the data to the mass-action law, respectively; n is the number of sets of dose–effect relationship experiments that were conducted
FIS fisetin, PTX paclitaxel

ISSN: 1475-2867