Drug combination | CI | Fa
| Interaction type |
---|
FIS (µM) | PTX (µM) |
---|
10 | 0.1 | 0.15 | 0.50 | Strong synergism |
20 | 0.2 | 0.22 | 0.60 | Strong synergism |
30 | 0.3 | 0.28 | 0.66 | Strong synergism |
40 | 0.4 | 0.33 | 0.70 | Synergism |
50 | 0.5 | 0.38 | 0.72 | Synergism |
- The CI values were calculated according to the method of Chou–Talalay using CompuSyn software. CI < 1 represents synergism, with CI of 0.1–0.3 indicating strong synergism, 0.3–0.7 indicating synergism, CI of 0.7–0.85 indicating moderate synergism, CI of 0.85–0.90 indicating slight synergism, CI of 0.90–1.10 indicating a nearly additive effect, CI of 1.10–1.20 indicating a slight antagonism, and CI of 1.20–1.45 indicating a moderate antagonism
-
Fa fraction affected by dose, FIS fisetin, PTX paclitaxel