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Table 2 The combination index values at actual experimental points for the combination of fisetin and paclitaxel

From: Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells

Drug combination CI Fa Interaction type
FIS (µM) PTX (µM)
10 0.1 0.15 0.50 Strong synergism
20 0.2 0.22 0.60 Strong synergism
30 0.3 0.28 0.66 Strong synergism
40 0.4 0.33 0.70 Synergism
50 0.5 0.38 0.72 Synergism
  1. The CI values were calculated according to the method of Chou–Talalay using CompuSyn software. CI < 1 represents synergism, with CI of 0.1–0.3 indicating strong synergism, 0.3–0.7 indicating synergism, CI of 0.7–0.85 indicating moderate synergism, CI of 0.85–0.90 indicating slight synergism, CI of 0.90–1.10 indicating a nearly additive effect, CI of 1.10–1.20 indicating a slight antagonism, and CI of 1.20–1.45 indicating a moderate antagonism
  2. Fa fraction affected by dose, FIS fisetin, PTX paclitaxel