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Table 2 The combination index values at actual experimental points for the combination of fisetin and paclitaxel

From: Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells

Drug combination

CI

Fa

Interaction type

FIS (µM)

PTX (µM)

10

0.1

0.15

0.50

Strong synergism

20

0.2

0.22

0.60

Strong synergism

30

0.3

0.28

0.66

Strong synergism

40

0.4

0.33

0.70

Synergism

50

0.5

0.38

0.72

Synergism

  1. The CI values were calculated according to the method of Chou–Talalay using CompuSyn software. CI < 1 represents synergism, with CI of 0.1–0.3 indicating strong synergism, 0.3–0.7 indicating synergism, CI of 0.7–0.85 indicating moderate synergism, CI of 0.85–0.90 indicating slight synergism, CI of 0.90–1.10 indicating a nearly additive effect, CI of 1.10–1.20 indicating a slight antagonism, and CI of 1.20–1.45 indicating a moderate antagonism
  2. Fa fraction affected by dose, FIS fisetin, PTX paclitaxel