Skip to main content

Table 2 Summarized molecular functions of the 22 TSGs according to the protein interaction network

From: Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy

Related function False discovery rate Number of the 22 TSGs Other genes
Cell cycle 7.14e−12 ~ 4.48e−2 PLK2, FBW7, TP53, PTEN, APC, BRCA1, CDKN1A, CDKN2A, ING4, RASSF1, PDCD4, FADD CUL1, CDK2, CDK4, CDKN1C, CDKN1B, GTPBP4, TP63, PHF17, BRMS1, STK4
Apoptosis 1.17e−9 ~ 1.16e−2 APC, REST, CDKN2A, FADD, ING4, TP53, Bax, BRCA1 BRMS1, TP63, FAS, STK4, CDKN1B, BCL2, CUL1
Protein ubiquitination 4.97e−9 ~ 4.39e−2 BRCA1, FBW7, TP53, CDKN2A, RASSF1, PTEN BTRC, CUL1, DAXX, GTPBP4, CDK2
Cell growth 1.29e−8 ~ 4.25e−5 PTEN, ING4, TP53, CDKN1A, CDKN2A, ING1, HIN-1 CDKN1B, PHF17, BCL-2, BRMS1