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Table 2 Summarized molecular functions of the 22 TSGs according to the protein interaction network

From: Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy

Related function

False discovery rate

Number of the 22 TSGs

Other genes

Cell cycle

7.14e−12 ~ 4.48e−2

PLK2, FBW7, TP53, PTEN, APC, BRCA1, CDKN1A, CDKN2A, ING4, RASSF1, PDCD4, FADD

CUL1, CDK2, CDK4, CDKN1C, CDKN1B, GTPBP4, TP63, PHF17, BRMS1, STK4

Apoptosis

1.17e−9 ~ 1.16e−2

APC, REST, CDKN2A, FADD, ING4, TP53, Bax, BRCA1

BRMS1, TP63, FAS, STK4, CDKN1B, BCL2, CUL1

Protein ubiquitination

4.97e−9 ~ 4.39e−2

BRCA1, FBW7, TP53, CDKN2A, RASSF1, PTEN

BTRC, CUL1, DAXX, GTPBP4, CDK2

Cell growth

1.29e−8 ~ 4.25e−5

PTEN, ING4, TP53, CDKN1A, CDKN2A, ING1, HIN-1

CDKN1B, PHF17, BCL-2, BRMS1