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Fig. 2 | Cancer Cell International

Fig. 2

From: Basigin-2 upregulated by receptor activator of NF-κB ligand enhances lung cancer-induced osteolytic lesions

Fig. 2

The regulation effect of basigin-2 on MMP-2, MMP-9 and VEGF expression in lung cancer cell. a The mRNA and protein expression of basigin-2 in A549 cells transfected with overexpression vector or siRNA detected by realtime RT-PCR and western blot, respectively. SNC means scrambled negative control of siRNA. After modulating basigin-2 expression, the downstream molecular MMP-2, MMP-9 (b) and VEGF (c) mRNA and protein expression level (proteinase activity for MMPs) were detected using realtime RT-PCR, gelatin zymography and western blot in A549 cells. *P < 0.05, compared to negative control (pcDNA3.1 or SNC), by Student’s t test

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