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Fig. 3 | Cancer Cell International

Fig. 3

From: Basigin-2 upregulated by receptor activator of NF-κB ligand enhances lung cancer-induced osteolytic lesions

Fig. 3

The furtherance role of basigin-2 on lung cancer cell invasion, metastasis and proliferation. a Effect of basigin-2 on the invasion and migration of A549 cells transfected with basigin-2 expression plasmid. b The invasion and migration of A549 cells transfected with basigin-2 siRNA were tested. SNC means scrambled negative control of siRNA. Morphologic comparison of cells penetrating the artificial basement membrane was shown. c and d Wound-healing assay of A549 cells transfected with basigin-2 expression plasmid or siRNA, respectively. *P < 0.05, compared to negative control (pcDNA3.1 or SNC), by one-way ANOVA followed by the Dunnett test. Scale bars 200 μm. e Cell proliferation of lung cancer cells transfected as above (a) and (b) was measured in the indicated time periods using MTT assay. *P < 0.05, compared to negative control (pcDNA3.1 or SNC), by 2-way repeated measures ANOVA followed by the Bonferroni test

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