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Fig. 5 | Cancer Cell International

Fig. 5

From: Basigin-2 upregulated by receptor activator of NF-κB ligand enhances lung cancer-induced osteolytic lesions

Fig. 5

Effect of RANKL on the expression of basigin-2 and its downstream genes. a A549 cells were treated with DMEM (negative control, NC) or with conditioned medium from primary mouse osteoblast cultures treated with vehicle (OBsCM) or OPG (OBsCM + OPG) for 48 h. The mRNA expression of basigin-2, MMP-2, MMP-9 and VEGF were detected by realtime RT-PCR. *P < 0.05, compared to negative control (NC), by Student’s t test. bd A549 cells were treated with 30 ng/mL RANKL for 4, 8, and 16 h. Then, the mRNA and protein expression level were measured for b basigin-2, d VEGF and proteinase activities for c MMP-2 and MMP-9. *P < 0.05, compared to 0 h, by Student’s t test

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