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Fig. 3 | Cancer Cell International

Fig. 3

From: LIN28B is highly expressed in atypical teratoid/rhabdoid tumor (AT/RT) and suppressed through the restoration of SMARCB1

Fig. 3

Effect of LIN28B knockdown on AT/RT cells. The level of LIN28B mRNA and protein was effectively inhibited after the transfection of LIN28B-siRNAs. a RT-qPCR and b western blot analysis showed that LIN28B knockdown reduced CCND1 expression and enhanced CDKN1C expression. c The increased expression of pre-leg-7g and mature let-7g miRNA was observed after LIN28B knockdown. *P < 0.05; **P < 0.01; ***P < 0.01. Error bars represent ±SD

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