Skip to main content
Fig. 6 | Cancer Cell International

Fig. 6

From: LIN28B is highly expressed in atypical teratoid/rhabdoid tumor (AT/RT) and suppressed through the restoration of SMARCB1

Fig. 6

Overexpression of SMARCB1in AT/RT, MB and glioblastoma cells. a Transfection efficiency of SMARCB1 was confirmed using RT-qPCR at 48 h after pEGFP-C2.SMARCB1 transfection. b Transfection with pEGFP-C2.SMARCB1 decreased LIN28B and CCND1 expression and increased CDKN1C expression. c Cell viability was significantly diminished after the introduction of SMARCB1. d LIN28B was suppressed and OCT4 was increased after the restoration of SMARCB1 expression in all AT/RT cells. However, the differential expression of LIN28A, SOX2, KLF4 and MYC was detected in all AT/RT cells. e In MB and glioblastoma, the expression of LIN28B, CCND1 and CDKN1C was unchanged after SMARCB1 knockdown. **P < 0.01; ***P < 0.001. Error bars represent ±SD

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us